Protein Modification Reagents
Medchemexpress LLC 3,6,9,12,15-Pentaoxahexadecanoic acid | 16024-66-1 | 99.9% | 100 MG
m-PEG4-CH2COOH is a PEG-based PROTAC linker, a colorless to light yellow liquid with a density of 1.125 g/cm³. With a molecular weight of 266.29 and chemical formula C11H22O7, it is primarily utilized in the synthesis of PROTACs. PROTACs are compounds designed to exploit the intracellular ubiquitin-proteasome system by linking an E3 ubiquitin ligase to a target protein, thereby selectively degrading the target.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Appears as a colorless to light yellow liquid
- Has a chemical formula of C11H22O7
- Features a molecular weight of 266.29
eMolecules 675606-79-8 | Fmoc-NH-PEG12-CH2COOH | Broadpharm | MFCD30723256 | 825.946 | C41H63NO16 | 97.000 | OC(=O)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 340377161
Fmoc-NH-PEG12-CH2COOH | Broadpharm | 675606-79-8 | MFCD30723256 | 825.946 | C41H63NO16 | 97.000 | OC(=O)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 340377161
Medchemexpress LLC (S,R,S)-AHPC-PEG5-COOH | 2172820-14-1 | 99.8% | 1 ML
(S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology. This product is for research use only and not sold to patients.
- Incorporates an (S,R,S)-AHPC-based VHL ligand
- Features a 5-unit PEG linker
- Utilized in PROTAC technology
- Recruits VHL protein, a substrate recognition subunit of Cullin RING E3 ubiquitin ligase complexes
- Induces ubiquitination and subsequent proteasomal degradation of target proteins
Sigma Aldrich Fine Chemicals Biosciences Collagenase Type I Cls I1G
This product is identical to Biochrom GmbH part numbers C1-22 and C1-28. Enzyme blends of collagenase clostripain with tryptic and proteolytic activities from Clostridium histolyticum. This preparation is recommended for liver lung adipose and adrenal tissue. Specific activity is 125 to 250 Mandl units per ml of powder substance.
Medchemexpress LLC Vh285-peg4-c4-cl | 1799506-07-2 | MFCD34601688 | >98.0% | 799.42 g·mol⁻¹ | C41H55ClN4O8S | 5 MG
VH285-PEG4-C4-Cl is a VHL-ligand-HaloTag conjugate designed as a targeted protein degrader for use in cellular and biochemical assays. It connects a VH285-based VHL ligand to a HaloTag-targeting moiety via a PEG4-C4 linker to induce proteasomal degradation of HaloTag fusion proteins. Supplied for research use with high stated purity and available in small quantities or as a DMSO solution.
- Highly potent degrader with a DC50 of 19 nM.
- Can induce up to 90% degradation of GFP-HaloTag7 in cells.
- VHL ligand-HaloTag conjugate with a PEG4-C4 linker for targeted engagement.
- Supplied with reported purity ≥98% and molecular weight 799.42 g·mol⁻¹.
- Available in small mg quantities or as a 10 mM solution in DMSO for reconstitution.
- Suitable for cellular and biochemical studies of targeted protein degradation.
eMolecules 2128735-20-4 | N-Mal-N-bis(PEG2-amine) TFA salt | Broadpharm430.502 | C19H34N4O7 | 98.000 | NCCOCCOCCN(CCOCCOCCN)C(=O)CCN1C(=O)C=CC1=O | 250mg | 354974835
N-Mal-N-bis(PEG2-amine) TFA salt | Broadpharm | 2128735-20-4430.502 | C19H34N4O7 | 98.000 | NCCOCCOCCN(CCOCCOCCN)C(=O)CCN1C(=O)C=CC1=O | 250mg | 354974835
Medchemexpress LLC N3-PEG4-C2-NHS ester | 944251-24-5 | 98.9% | 1 G
N3-PEG4-C2-NHS ester is a non-cleavable 4-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). It is a click chemistry reagent containing an azide group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Non-cleavable 4-unit PEG linker
- Used in the synthesis of antibody-drug conjugates (ADCs)
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
eMolecules 2055042-59-4 | N-(Amino-PEG3)-N-bis(PEG3-acid) HCl salt | Broadpharm | MFCD30182040 | 600.703 | C26H52N2O13 | 97.000 | NCCOCCOCCOCCN(CCOCCOCCOCCC(O)=O)CCOCCOCCOCCC(O)=O | 500mg | 309208956
N-(Amino-PEG3)-N-bis(PEG3-acid) HCl salt | Broadpharm | 2055042-59-4 | MFCD30182040 | 600.703 | C26H52N2O13 | 97.000 | NCCOCCOCCOCCN(CCOCCOCCOCCC(O)=O)CCOCCOCCOCCC(O)=O | 500mg | 309208956
eMolecules 100688-48-0 | m-PEG3-(CH2)3-alcohol | Broadpharm | MFCD26841942 | 178.228 | C8H18O4 | 98.000 | COCCOCCOCCCO | 1g | 368397786
m-PEG3-(CH2)3-alcohol | Broadpharm | 100688-48-0 | MFCD26841942 | 178.228 | C8H18O4 | 98.000 | COCCOCCOCCCO | 1g | 368397786
eMolecules 1421933-39-2 | Bromoacetamido-PEG3-Boc-amine | Broadpharm | MFCD23378554 | 413.309 | C15H29BrN2O6 | 95.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCNC(=O)CBr | 1g | 550803931
Bromoacetamido-PEG3-Boc-amine | Broadpharm | 1421933-39-2 | MFCD23378554 | 413.309 | C15H29BrN2O6 | 95.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCNC(=O)CBr | 1g | 550803931